Daisy-Hill Dachshunds

Every Breeding Dachshund Adult

has been tested for

3 Genetic Diseases

Results for each dog may be found on their own page.

 Dogs can be found on the tabs above

OUR BOYS & OUR GIRLS

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Responsible Breeders of purebred dogs are well aware that  Inherited Diseases can be controlled by careful, selective breeding programs. Information regarding the test results from the Sire and Dam, along with information on other close relatives such as siblings, half-siblings, aunts and uncles

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Allows Breeders to apply greater selective pressure to

Produce Normal Offspring and Avoid Affected Offspring.

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Genetic Health Tests:

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Progressive Retinal Atrophy, cone-Rod dystrophy 4 (PRA-crd4) is an inherited eye disease affecting Miniature Dachshunds. PRA-crd4 occurs as a result of degeneration of both rod and cone type Photoreceptor Cells of the Retina, which are important for vision in dim and bright light, respectively. Affected dogs can show symptoms of vision loss or have signs of retinal disease on veterinary ophthalmologic exam by 3 years of age. However, age of onset varies significantly in PRA-crd4 affected dogs, and has been reported from 1 to 15 years of age. Mutations in the RPGRIP1 gene show Incomplete Penetrance, meaning that not all dogs inheriting two copies of the Mutation develop clinical disease. This suggests that other unknown genetic or environmental factors may play a role in modifying disease development and progression. Although progression tends to be relatively slow, most affected dogs (especially those with an early age of onset) will progress to complete blindness.

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Neuronal Ceroid Lipofuscinsosis 1 (NCL1) is a rare lysosomal storage disease identified in a Miniature Dachshund. NCL1 is due to a deficiency in the Enzyme palmitoyl protein thioesterase (PPT1), which is necessary to break down certain proteins in the cells. As a result, there is an accumulation of these compounds in cells, which affects the normal function of the brain and nervous system. The affected dog presented with progressive neurologic disease at 9 months of age though the owner stated that the symptoms began a “number of months” earlier. Symptoms included a lack of muscle coordination, arched back, abnormal gait, and difficulty balancing and jumping. The dog also displayed signs of Dementia including aimless wandering behavior with episodes of confusion, depression, aggressive behavior, loss of learned behavior, blindness, seizures and frequent barking. These symptoms rapidly became more severe and the dog was euthanized at 14 months of age.

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Osteogenesis Imperfecta (OI) is an inherited Collagen disorder affecting dogs. Affected dogs typically present between 3 to 4 weeks of age with pain, lameness and fractures. OI is caused by a defect is in the way collagen is made. Because collagen is an important component of bone, bones of affected dogs are thinner than normal, fracture easily and do not heal properly. Other features of the disorder include loose joints and brittle teeth. Because of the severity of the disease, pups with OI are usually euthanized by 3 months of age.

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Lafora Disease is an inherited neurological disease affecting miniature wirehaired dachshunds. Affected dogs typically present after 5 years of age with progressive, partial to generalized seizures due to an abnormal accumulation of large carbohydrate molecules in the brain. As the disease progresses, affected dogs may display other clinical signs including vision loss, deafness, Dementia, myoclonus (involuntary muscle jerks), aggression, tremors, “flybiting” behavior (attempting to catch nonexistent flies), jaw smacking, urinary and fecal incontinence, loss of house training, and/or abnormal gait. Excitement or nervousness, exposure to flickering lights, sudden sounds or movements may trigger seizure activity in some affected dogs. Seizures caused by this type of epilepsy have mixed response to treatment, becoming less effective as the disease progresses. Affected dogs are typically euthanized by 10-12 years of age due to decline in quality of life.

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